What are some different chemical methods to induce Myeloid leukemia in animal model?

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Jacek Koziorowski

You can use polycyclic hydrocarbons, e.g. methylcholanthrene.

Google: "methylcholanthrene" and"methylcholanthrene induced tumors"

Fedor Vitaliyevich Donenko

Leukemia induced in animals by tyrosine metabolite. There are many data about these models in animals in 60-80 years. It is theory of "endogenic cancerogenesis".

@Fedor; reference(s) / paper(s) please.

Pankajkumar Chhatrala

I found few papers describing series of experiments done by C. Huggins.

He has described DMBA emulsion in LE rats.

@Pankajkumar; yes - 7,12-Dimethylbenzanthracene (DMBA) is a polyclic hydrocarbon.

Charles Benton Huggins got the Nobel prize in medicine in 1966 for his cancer research.

This is more only for Jacek

[Effect of the carcinogenic tyrosine metabolite p-hydroxyphenyllactic acid on the ascorbic acid concentration in the organs and blood of mice].

Levchuk AA, Faron RA, Khrustalev SA, Raushenbakh MO.

Biull Eksp Biol Med. 1986 Oct;102(10):462-3. Russian.

You can find more reference, if you want by tyrosine metabolite p-hydroxyphenyllactic acid.