I did orthopedic surgery on my mouse yesterday and for surgical prophylaxis, I had 10 mg of intraperitoneal cefazolin injection 30min before surgery, then once every day for 5 days 10mg of cefazolin will be injected intraperitoneally, today when I checked my mouse, I saw sth around the patella that swelled outward, I want to know if it's ok and it's sth normal like inflammation or its sth serious like infection or abscess, and what should I do with that, if it's the inflammation should I use NSAIDs or if it's infection, should I change or add another antibiotics?
I always give analgesia like buprenorphine just before surgery and than morning/evening for three days post-surgery. That has worked very well in Nude rats. But normal mice even need less analgesia. You are giving antibiotics before and post-surgery. May be you should include some analgesia also. Swelling first day, I will be of some concerned but can not do much and will wait for 2/3 days, hope that will be go down. If any internal suture has not broken, sometime it can happen also. If veterinarian around, you should address this question to him/her. And watch your mouse morning /evening for few days regularly. Mice in general heal faster than other animals like rabbit.
Subhash C. Juneja Thank you professor, yes we for sure gave them analgesia, for intra femoral injections, mice were anaesthetized with 10 mg/ml ketamine/xylazine, but as you mentioned we should also consider buprenorphine and thanks for that, and more to all of this our mice were given chemotherapy drugs and they are immunocompromised, and because of that I'm a little worried about that swelling.
The dose I used: injection of analgesia (Buprenorphine, 0.03mg/kg) one injection just before surgery and one in AM and one in PM for 3 days post-surgery. That will be good idea to include besides your antibiotics.