Amount studies on beta cells have used INS-1 cell and INS-1E cell, and I wondering wheather there are differences between them.
Best regard.
Hello Hcheng Zhang
INS-1 cells which are isolated from a radiation-induced rat insulinoma due to the nonclonal nature are heterogeneous and have limited stability over extended culture periods. This probably may explain the discrepancies observed when using the parental INS-1 cells.
On the other hand, INS-1E cells are clonal in nature derived from parental cells based on both their insulin content and their secretory response to glucose. The clonal INS-1E beta-cell line has proven to be instrumental for numerous studies investigating the mechanism of glucose-stimulated insulin secretion.
You may want to refer to the article attached below for more information.
Article Glucose Sensitivity and Metabolism-Secretion Coupling Studie...
Best.
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