Coffee is a simple beverage, but it’s full of complex compounds with health benefits. It contains hundreds of bioactive components including vitamins, minerals, and anti-inflammatory polyphenols such as flavonoids. The amount of caffeine in a cup of coffee can vary, depending on factors ranging from the type of bean used. So, What about the healthy daily amount of caffeine was recommended to be healthy with no risk?
Dear Wesam Salah Ibrahim ,
Greetings!!
Probably it will be useful to look for toxicity data available regarding caffeine. Please visit this link in TOXNET containing information regarding caffeine: https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+36
Hope it helps your query.
Best Regards,
Samrat
Up to 400 milligrams (mg) of caffeine a day appears to be safe for most healthy adults. That's roughly the amount of caffeine in four cups of brewed coffee, 10 cans of cola or two "energy shot" drinks. Keep in mind that the actual caffeine content in beverages varies widely, especially among energy drinks
Caffeine clearance by liver depends on CYP enzyme and people with SNP have decreased clearance. This can impact caffeine effects on an individual basis. The enzyme is also responsible for xenobiotics, including intermediates from smoking. Below is a good article that discusses the enzyme, as well as relationship of coffee caffeine intake with smoking's effect on liver caffeine clearance. More articles are available about caffeine and CYP SNPs.
Yang A, Palmer AA, de Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology (Berl). 2010;211(3):245–257. doi:10.1007/s00213-010-1900-1
Article Erratum to: The influence of a CYP1A2 polymorphism on the er...
The above full text open access article is another excellent paper addressing caffeine clearance linked to CYP polymorphisms, but this article Fiann Paul you may specifically enjoy and appreciate because it looked at the effect of the CYP SNP in athlete cyclists and the ergogenic effect the SNP had on the cyclists.
As per the guidelines/suggestions of Food safety and standard authority of India, Min of health and family welfare, GoI, the maximum consumption should not be 180mg/day. If it is more and regular consumption may lead to adverse neurological consequences
Dear Wesam Salah Ibrahim ,
Greetings!!
If you are considering special cases like "during pregnancy", then as per WHO recommendations, "........For pregnant women with high daily caffeine intake (more than 300 mg per day), lowering daily caffeine intake during pregnancy is recommended to reduce the risk of pregnancy loss and low birth weight neonates........" (Website Link: https://www.who.int/elena/titles/caffeine-pregnancy/en/ )
Up to 400 milligrams (mg) of caffeine a day appears to be safe for most healthy adults. That's roughly the amount of caffeine in four cups of brewed coffee, 10 cans of cola or two "energy shot" drinks. Keep in mind that the actual caffeine content in beverages varies widely, especially among energy drinks.Mar 8, 2017.
Best regards
Four cups of coffee a day
https://www.nhs.uk/news/genetics-and-stem-cells/four-cups-of-coffee-not-bad-for-health-suggests-review/
Best Regards Wesam Salah Ibrahim
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