If Moderna or Pfizer in America and BioNTech in Germany filled their Covid19 jab vials in Air, rather than an inert gas like Nitrogen or Argon, we can expect residual Ethanol to be oxidized to Ethyl Hemiacetal and 1,1-Diethoxyethane (also known as Acetal and a host of synonyms) and further oligomers.
The oxidation will vary depending on light exposure and the possible catalytic effects of the vial surface.
This could lead to instability of the jabs and account for the high incidence of Adverse Reactions, varying between Batches.
Geoff Pain
Interesting idea. There may be oxidation. The idea should be checked by COVID specialists,
I am not sure about the COVID vaccines. But regarding the formation of acetaldehyde over time, it is possible that small amounts of acetaldehyde can form in the vaccines over time, as the vaccines contain trace amounts of a component called polyethylene glycol (PEG), which can break down into acetaldehyde. However, the levels of acetaldehyde are likely to be very low and are not expected to pose a significant health risk to individuals receiving the vaccines.
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Daer Geof Pain
As far as i know, the primary solutions and buffers used to encapsulate mRNA within lipid nanoparticles, would be completely eliminated by TFF and replaced by PBS or other safe buffers. Nevertheless, the possible remained ethanol and other ingredients involved in upstream steps should be checked by QC departments.