Current drug recommendations
Below you can see six of the approaches taken to use of drugs against covid itself. There is a real east west divide and I am beginning to wonder if it is going to cost, or is already costing lives here, as well as increasing, or going to unnecessarily increase, the demand on ICUs. Dr Zhang in Wuhan who wrote The Lancet paper in mid February with its triage flowchart including drug therapy told of the need to get in early with it. He also favoured post exposure prophylaxis. Umifenovir (Arbidol), respiratory quinolones (floxacins), linezolid are in the chart. Drug therapy is also true of the guide produced by Zhejiang Uni hospital, who say they lost no patients, just as Dr Zhang lost no staff.
Drugs aimed at the virus Australia
ACEM guide - none, other than in a recognised trial See https://acem.org.au/getmedia/78105c4b-5195-43f6-9c91-25dda5604eaf/Clinical-Guidelines-for-the-management-of-COVID-19-in-Australasian-emergency-departments
WHO None. See https://apps.who.int/iris/rest/bitstreams/1272156/retrieve US None, other than recognised trial, but options provided for those who want to use them with appropriate precautions and contraindications See https://www.cdc.gov/coronavirus/2019-ncov/hcp/therapeutic-options.html China (as at 3.3.20) Lopinavir/ritonavir, chloroquine or hydroxychloroquine, umifenovir (Arbidol), interferon alpha, ribavirin, with appropriate precautions and contraindications. Traditional Chinese medicine using formulae including either pseudoephedrine or andrographolide See https://www.elotus.org/promo-files/COVID-19_resources/Guidance%20for%20Corona%20Virus%20Disease%202019%20(English%207th%20Edition%20Draft).pdf Russia (as at 2.3.20) Lopinavir/ritonavir, chloroquine or hydroxychloroquine, including for post exposure prophylaxis, interferon beta 1b, interferon alpha 2b intranasally for children, all with appropriate precautions and contraindications. Notes WHO Fortaleza guidelines for offlabel use. Paracetamol as antipyretic. No interferon alpha as it increases inflammatory factors. See https://static-1.rosminzdrav.ru/system/attachments/attaches/000/049/329/original/Временные_МР_2019-nCov_03.02.2020_%28версия_2%29_final.pdf?1580748451 esp. pp. 14-16 UK NICE guide - none aimed at the virus itself, although there are recommended drugs for palliative care See
https://www.nice.org.uk/guidance/ng163/chapter/3-General-advice-for-managing-COVID-19-symptoms On aspects relating to NSAIDs and corticosteroids see eg. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105332/
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