Dear coleagues,
Recently, I have cought the task to extract circulating DNA from whole blood. Unfortunately, the extraction/purification kit I have in the lab allows to take in processing no more than 100 ul separated plasma. Actually, I use kits developed for DNA extraction from whole blood. So, as you could suppose there is no any DNA after extraction in most samples except few ones.
Could anyone suggest to me a simple and robust approach for precipitation of plasma proteins with simultaneous volume reduction (but without loss of DNA) for further processing by (above described) kit.