I will work on a project. Which method should I use to imaging the tumor on the mice?
Can you elobrate your question more.
Tumor image system for mice, you are actually trying to develop a hardware based system or you are trying to detect the tumor from the exiting captured images ?
After injecting the cells into the mice, we want to imaging the spread of the tumor in the body (fluorescence imaging)
Dear Omur, will you be using a fluorescence scanning device? This is what would most applicable i presume. Once you have volumetric spread you might be able to perform 3d imaging and potentially use automated segmentation methods.
several companies are working on this, i do refer to:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209452/
on this page:
Both the phantom and in vivo mouse studies showed that superficial fluorescence signals could be imaged accurately. The SPECT and bioluminescence images could be used to place the fluorescence findings in perspective, e.g. by showing tracer accumulation in non-target organs such as the liver and kidneys (SPECT) and giving a semi-quantitative read-out for tumor spread (bioluminescence).
the easier method would be to use label the tracer or cells with a spect tracer.
Please your comments, peter
Agree with Peter, however, using µPET rather than SPECT will give you much more detection sensitivity and a better spatial resolution.
Dear Joel, thanks for adding this, i do agree. In case PET tracers are available they are to be used by preference. Not all centers have access to PET tracers and scanners, Spect might be more easily available, Peter
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