Does anyone works with or has came across any research article describing the tumor cells which primarily depends on anti-apoptotic/pro-survival protein Bcl-XL for their survival? From Bcl-XL dependence I mean that any tumor cell line which shows sensitivity towards Bcl-XL inhibitors, but insensitive to inhibitors of other anti-apoptotic members of bcl-2 family such as Bcl-2 or Mcl-1?
I don't know whether this can be generalized
but here is a case where Mcl-1 is the dominant
pro-survival protein and not Bcl-xL.
https://www.eurekalert.org/pub_releases/2010-10/waeh-csp100710.php
Other:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845080/
https://www.eurekalert.org/pub_releases/2010-03/rup-otr031610.php
http://www.news.vcu.edu/article/Researchers_develop_new_method_for_fighting_leukemia
http://cancerres.aacrjournals.org/content/73/17/5485
Regards,
Joachim
Hello Dr Pimiskern,
I appreciate you for adding an answer to this query. I could able to find out that MOLT-4, an acute lymphoblastic leukemia cell line, primarily depends on Bcl-xl for survival as demonstrated by its sensitivity towards Bcl-xl-selective inhibitors, but not to bcl-2-selective inhibitors.
https://www.ncbi.nlm.nih.gov/pubmed/25787766
Thank you
See this paper as well for BCL-XL-dependent colorectal cancer cell lines (determined w siRNA and BCL-XL-selective small molecule inhibitor A-1155463):
https://www.ncbi.nlm.nih.gov/pubmed/26134786
- Badges
- Science topic
- Similar topics
- Methodology
- Laboratory
- Cellular Biology Techniques