Does Metformin (1,1-dimethylbiguanide, MCE HY-B0627), which is commonly used in clinical practice, have a distinct taste?
Recently, when mice were given drugs by gavage, it was found that the animals had a significant resistance to the dissolved drug solution (refusing to eat and vomiting the drug), and it was suspected that it was related to the taste characteristics of the drug.
If the taste affects the drug administration, how do you usually optimize the formula (such as adding flavoring agents, adjusting the concentration, etc.)?
[Troubleshooting Questions are selected from MCE customer consultation emails.]
Metformin itself has a certain bitter taste, and some experimental mice may refuse to eat due to taste stimulation.
In animal experiments, the following dosing methods can be optimized:
1. Mixed administration with feed:
Mix the drug evenly with the mouse feed and administer the drug through spontaneous ingestion;
2. Solution gavage administration:
Dissolve in a suitable solvent (such as PBS or saline) and administer directly through a gavage needle.
It is necessary to adjust the drug concentration and administration volume according to the experimental design, and set up a blank control group to observe the difference in animal feeding behavior.
The answer to this question comes from MedChemExpress (MCE) Technical Support.
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