I am working on toxicity induced by drugs on invivo model(mice) and few compounds that have antioxidant properties that would be used to reduce this toxicity. The organs I would be looking for would be liver, kidney, ovaries, brain, heart. My question is to study antioxidant profile, what would be better to analyse antioxidant enzymes Serum or tissues?
liver is the best one
but if you know the active gradient and its mode of metabolism or excretion you can choice the organ related
ORAC is a method of measuring antioxidant capacities in biological samples. It is mainly used in patients who are undergoing radiation therapy.
It is better to use the tissue organ (Liver or Kidney ..etc) in which these compounds are affected and then take the serum with it to better confirm the results.
Kotwal Shifa Bushra
