Theoretical human proteome quantification profile.

04 April 2012 1 7K Report

I was wondering how can we make a theoretical human proteome quantify profile? Is it possible to do it? I mean there is a paper from Gygi SP (http://www.ncbi.nlm.nih.gov/pubmed?t...%202000%20PNAS) where they used Codon bias to evalute 2-DE. However, codon bias can not be used on human. There is emPAI (http://www.ncbi.nlm.nih.gov/pubmed?t...n%202005%20MCP) introduce by Mann. Here you need to have experiment data also. Is there software where we can give the human proteome database such as UniProtKB/Swiis-Prot and give us some index for abundancy of proteins?

Gaurav Bhardwaj

It is really a good idea but do you think that would we able to quantitate human proteome? Human Proteome is very dynamic and expression varies from individual to individual as well as tissue to tissue.

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