I would like to learn more about the related HCV it's risk and geographic distribution. A recent paper from University Paris 6, cited Egypt as having prevalence of between 15-20% of the population. Thanks for information about mode of infection, mortality and prevention.
I would refer you to the following papers : Shepard, Finelli and Alter,iLancet Infect Dis 2005; 5: 558–67ii
With a 10 page review
And
A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt.
AuthorsSievert W, et al.
Liver Int. 2011 Jul;31 Suppl 2:61-80. doi: 10.1111/j.1478-3231.2011.02540.x.
Following is an excerpt from the above
METHODOLOGY: Data references were identified through indexed journals and non-indexed sources. In this work, 7770 articles were reviewed and 690 were selected based on their relevance.
RESULTS: We estimated that 49.3-64.0 million adults in Asia, Australia and Egypt are anti-HCV positive. China alone has more HCV infections than all of Europe or the Americas. While most countries had prevalence rates from 1 to 2% we documented several with relatively high prevalence rates, including Egypt (15%), Pakistan (4.7%) and Taiwan (4.4%). Nosocomial infection, blood transfusion (before screening) and injection drug use were identified as common risk factors in the region. Genotype 1 was common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 was found in Vietnam and other Southeast Asian countries. In India and Pakistan genotype 3 was predominant, while genotype 4 was found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria.
Thank you Anu for the rapid answer. So Chin comes number 1 in the number of infected persons though if we consider the rates Egypt comes first. This percent if very alarming, I wander what kind of prevention program is applied in Egypt!. Do you think the genotype 4 is more difficult to control?
Thanks
Early reports on the treatment of patients with chronic HCV-4 with conventional interferon (IFN)-alpha monotherapy indicated poor rates of sustained viral response (SVR), which improved slightly when combined with ribavirin. Pegylated IFN and ribavirin combination therapy has dramatically improved the response rates, with recent clinical trials showing rates that exceed 60%. QRecent clinical trials show that HCV-4 is not difficult to treat, as the response to treatment may be at an intermediate level compared with genotype 1 and genotypes 2 or 3. Tailored treatment options that are comparable to the treatment approaches for genotype 1, 2, and 3 patients to optimize treatment for each patient are now being developed.
Check also the following review article : How to optimize HCV therapy in genotype 4 patients. Gamal Esmat, Mohamed El Kassas, Mohamed Hassany, Mohamed Esmat Gamil and Maisa El Raziky
Available at
http://onlinelibrary.wiley.com/store/10.1111/liv.12059/asset/liv12059.pdf;jsessionid=671C8EF62CE9E40C85AF08324E660024.f01t03?v=1&t=hovfvxod&s=0dc6ff139f4285cc7cc25fb95d0b27e162c2be8e&systemMessage=Wiley+Online+Library+will+be+disrupted+on+7+December+from+10%3A00-15%3A00+GMT+%2805%3A00-10%3A00+EST%29+for+essential+maintenance
Thank you very much for your answers Anu. Could you please give some info or reference for the prevalence of HCC due to HCV infection? Thanks
Check http://www.cdc.gov/hepatitis/Populations/PDFs/HIVandHep-FactSheet.pdf for coinfection prevalence stats and also the following:
Anderson, KB; Guest, JL; Rimland, D (November 2004). "Hepatitis C virus coinfection increases mortality in HIV-infected patients in the highly active antiretroviral therapy era: data from the HIV Atlanta VA Cohort Study". Clinical Infectious Diseases 39 (10): 1507–13. doi:10.1086/425360. PMID 15546088.
Bräu, N (February 2005). "Treatment of chronic hepatitis C in human immunodeficiency virus/hepatitis C virus-coinfected patients in the era of pegylated interferon and ribavirin". Seminars in Liver Disease 25 (1): 33–51. doi:10.1055/s-2005-864780. PMID 15731996.
It is reported %1.5 -%3.5 in European population ,high prevalence in Egypt (%20) .Prevalence of HCV is reported nearly %15
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