Dear all,
Your kind advise is needed here: I am working with mice- in which we initiate a trauma for inflammation activation. I am planning to block one of the anti-inflammatory cytokines' receptors. My Questions is: Is the activation of the innate immunity after a trauma goes in parallel with the anti-inflammatory cytokines activation? Or in other words, what is the best time to block one of the anti-inflammatory cytokines' receptor after initiating the trauma?
Am thankful already :)
With my Best Reagrds, Alaa
I would block within the first 24 h (because IL-10 levels peak around 24 h in females).
And do you have an idea about the IL-4 as well as IL-13 cytokines peak time? Thanks :)
Generally, the immune response after trauma, infection, sepsis, starts first with the activation of Th1 immunity and proinflammatory cytokine production (SIRS). As our body knows, how dangereous for our organs can an uncontrolled hyperinflammation be (multiorgan dysfunction syndrom, multiorgan failure, failure of microcirculation, death due to cytokine storm even in the absence of microorganisms), approximately 10-24 hours later starts with the compensatory antiinflammatory response (CARS)) - with the production of Th2 (IL-4, ...) cytokines and production of antiinflammatory cytokines (IL-10). The aim of this is to perform a balance. If this compensatory antagonistic response is too strong, the Th1 immunity together with inflammation is strongly inhibited, and it can lead to immune depression even immune paralysis that might be the cause of development of e.g. polymicrobial sepsis. Note: the higher of hyperinflammation is, the higher the compensatory antiinflammatory response will be.
Cave: Patients with head trauma or patients suffering from immune deficiency can from the beginning start with Th2 immunity and CARS, that means without hyperinflammation and Th1 immunity actovation.
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