Hi,
I would like to ask for a help from the Research Gate community regarding a statistical analysis. My case is analyzing the association between the concentration of HIV DNA prior to therapy (time point 0) and the concentrations of biomarkers of HIV infection after therapy, measured in 6 time points with an interval of 6 months between each time point.
Research question: is there a relationship between the concentration of HIV DNA prior to therapy and the longitudinal expressions of immune activation markers during antiretroviral therapy (ART)?
Study design: graph in attachment
Sampling: graph in attachment
I have had feedbacks:
(1) analyzing a dependent variable collected in multiple time points by 'repeated measures anova'
(2) analyzing the correlation to explain causality of the independent variable (collected in t0) and the dependent variable (collected in t6,12,18,24,30,36) using 'linear regression'
What would you suggest to analyze the outcomes of the measurements, particularly to explain whether the concentration of HIV DNA prior to therapy is a predictor of biomarker expressions after therapy?
Thanks