Allicin is a natural antibiotic phytochemical. It has other properties like anticancer, anti-tumor, anti arthritic, antidiabetic etc. However, it is very unstable in nature. What are the possible methods/strategies to enhance stability of this bioactive compound? Can it be used against multidrug resistant bacteria?
You can try to denature the enzyme allinase 1st. See this article in Wiki;
https://en.wikipedia.org/wiki/Allicin
It is also reported for tuberculosis, if I remember correctly. One could look into MDR aspect. Stability is an issue. But Prodrug might be an answer I Guess. Interesting area of research.
Try to eliminate conditions of oxidation. Compound the API in a tank covered by Nitrogen gas. Denature the enzyme by lowering the pH with citric acid.
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