How to detect or measure drug compounds in beta cyclodextrin inclusion complex?

Souptik Bhattacharya @Souptik_Bhattacharya

09 September 2019 1 4K Report

What is the analytical method and instrument required to detect the drug which formed inclusion complex with beta cyclodextrin? How can it be detected?

Hanan Azzam

There are many analytical techniques to determine the CD-drug complex qualitatively and quantitatively for example

UV-spectroscopy and HPLC to detect dissolution constant and for loading and release study

Infra red technique (IR)

DSC ,SEM techniques

You will see different techniques in leatreature review..

Badges
Science topic

More Souptik Bhattacharya's questions See All

How to extract/release a drug compound from beta cyclodextrin inclusion complex?

Is there any method to release or extract the drug molecules from beta-cyclodextrin inclusion complex? I want to release a drug from the complex, can I degrade or dissolve the cyclodextrin part?

08 September 2019 1,841 2 View

Can I do molecular dynamics simulation of a compound diffusing through a biological membrane?

I need to know the mechanism of action, so is there any in silico technique? Please suggest some liturature if you can. Thanking you in anticipation.

05 June 2019 5,758 4 View

How can I do molecular dynamics simulation of a docked protein-ligand compound file after docking?

I used Autodock VINA for docking.

05 June 2019 228 8 View

From where can I purchase antibiotic resistant bacterial strain such as MRSA in India for research purpose?

Can I select the resistant strain from a susseptible strain population using any method or do I have to purchase it from strain repository?

02 March 2019 4,678 8 View

Stability enhancement of allicin

Allicin is a natural antibiotic phytochemical. It has other properties like anticancer, anti-tumor, anti arthritic, antidiabetic etc. However, it is very unstable in nature. What are the possible...

01 January 1970 8,009 3 View

I am interested in medicinal chemistry field, which books are highly recommended to learn from?

I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...

02 March 2021 8,437 2 View

Benefits of the 24 welled plate?

We have always used the 96 welled plate, the 48 welled plate but apparently there is much evidence on the 24 welled plate and above all its benefits.It states it is the same you would use on ELISA...

28 February 2021 1,149 1 View

How to compare 2 samples recruited with different sampling methods?

If I want to compare characteristics of 2 groups of patients, one group is recruited from a random sample of the general public while another group is from a sample with a fixed gender (male to...

26 February 2021 3,526 3 View

Can random sampling have inclusion criteria?

As random sampling means that everyone in the population have an equal chance to be chosen, can it have inclusion criteria? My research participants have been chosen based on the inclusion...

26 February 2021 6,905 10 View

How to empty large intestine in mice ?

Hi all I am working on colon-targeted drug delivery for which I kept mice fasting for 6h using fasting grills during scotophase (dark period). I observed liquid fecal content in the cecum and...

23 February 2021 7,701 2 View

Can I use a protein-devoid condition as my negative control in ELISA?

Hello, I am running a sandwich-type ELISA where I am trying to inhibit a protein-protein interaction using small molecules. For each experiment, I determine my Z' (Z-prime) to determine the...

23 February 2021 7,429 1 View

How does the injection volume impact LLOQ and ULOQ in regression analysis (LC-MSMS)?

Hello, I have run into an issue that has sparkled a debate at work: is the LLOQ/ULOQ impacted by injection volume under the following circumstances: 1) Same dilution factor of all samples 2)...

23 February 2021 9,159 3 View

Can two EC50 values with different hill slopes be compared?

Hello, I fit a classical dose response curve Y=Bottom + (Top-Bottom)/(1+10^((LogEC-X)*HillSlope)) to my data (not related to inhibitors etc). The model I use is purely qualitative but it fits...

23 February 2021 8,155 5 View

What does it require to be ready for e-Commerce in developing countries?

Most developing countries are not ready for e-Commerce? What dimensions and indicators are there to measure e-commerce readiness of a nation? Please share framework or model and evaluation...

22 February 2021 8,132 6 View

Do you consider undergoing a structure literature review / Meta analysis and getting numerical findings sort of quantitative method?

I am looking for a classification of the research methods included in literature review papers or Meta analysis ones .

22 February 2021 1,131 4 View