I have built a new method of reconstructing gene regulatory networks and am having trouble finding reputable sources for ground truth GRNs.
Several of the databases I have found seem to use pre-existing computational methods to compute GRNs and are thus not sufficient for evaluating new methods of computing GRNs.
Is there a set of widely accepted GRNs that have been heavily experimentally validated with some sort of regulatory importance metric that I can use to evaluate my method?
Jason W Hoskins
Not that I know of, and I doubt that one exists. I would think it best to benchmark your GRN inference method with simulated networks of varied sizes and topologies and compare its efficacy against other popular methods.
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