I would like to contact someone working with cafestol or coffee diterpenes. It is of my interest to know the future in pharmaceutics of these compounds.
Cafestol shows in EXPERIMENTS some potentially proatherogenic /proatherosclerotic effects due to a post-transcriptional downregulation of the LDL receptor. However, in reality , if humans moderately drink boiled coffee (3 or 4 cups daily) the effect on cholesterol levels is very unlikely to be significant. Filtered coffee seem to have a neutral effect on lipid levels in humans. Cafestol shows in experiments anti-angiogenic . anti-tumorigenic and hepatoprotective effects.It shows pleiotropic effects and currently nobody can exactly tell the future of the cafestol and other coffee diterpenes in pharmaceutucs. As for plasma LDL increasing effects: Cafestol increase serum LDL and transiently serum triglycerides, but lipid effects in humans depends on genetic make up of an individuum. A lot of research is needed to have conclusive results. Good luck
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