i am working with a water insoluble drug and my aim is to load it on mesoporous nanoparticles. i tried suspended the nanoparticles in pbs and dissolving the drug in DMSO, but when i mix both, the drug itself percipitates. is it possible to use acetone as a loading solvent? i intend to use the nanoparticles for a medical application later.
What is the nature of the mesoporous nanoparticles? Are you sure the drug is precipitating and not the particles? You can use acetone if it dissolves your drug, but given that you do not provide much information this is all I got.
Omar Gonzalez-Ortega i made a quick test, dissolved the drug in dmso then added pbs and centrifiguged this mixture, then i observed that the drug percipitated. thus i am afraid that if i mix it with the nps and then centrifiuge , i will get a pellete of both nps and ppt of the drug.
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