I have genotype of 400 people, only 102 SNPs. There were target for genetics lifestyle report. They are divided between Brazilians and Swiss.
My research now is to look at few SNPd and calculate a GRS score then to check the differences among these 2 group populations.
From the 102 genes I have selected only 20. We have another data, life BMI, physical activity, age, nationality, and place of residence.
Do you have an ideia, besides basics Statistics and alleles frequency how I can create the GRS scores and calculate more advanced parameters? I have been reading lots of papers, however my background is more clinical nutrition.
Thank you in advance
Viviane
Dear Viviane da Silva Anastacio
The way I interpret is you have genetic profiling data (some sequencing ? or using other techniques like micro-array? or multiplexing pcrs?) whatever and you want to associate your 102 polymorphisms identified between two groups based upon races. The comparison of the identified polymophisms probably will be done by genetic risk scoring.
Few question:
1- Type of genetic data source?
2- Will you do genotype-phenotype (lifestyle) comparison for GRS?
3- Your exact OBJECTIVE
Regards
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