Dear everyone,
I am looking for a Rotundin (also Tetrahydropalmatine) extraction process from Stephania spp.
I just have some simple equipments. The solvent is limited to water and ethanol because of the safety. I also have some acid and base to adjust pH if neccessary.
I need not to get high purity of rotundin.
Could you please give me some advises for this situation?
Thank you in advance!
Dear Sir. Concerning your issue about the Rotundin/Tetrahydropalmatine extraction. Levo-tetrahydropalmatine (l-THP) is an active constituent of herbal preparations containing plant species of the genera Stephania and Corydalis and has been approved and used in China for a number of clinical indications under the drug name Rotundine. The pharmacological profile of l-THP, which includes antagonism of dopamine D1 and D2 receptors and actions at dopamine D3, alpha adrenergic and serotonin receptors, suggests that it may have utility for treating cocaine addiction. In this review, we provide an overview of the pharmacological properties of l-THP and the evidence supporting its development as an anti-addiction medication. The results of preclinical work demonstrating that l-THP attenuates cocaine’s reinforcing/rewarding effects and reinstatement in rat models of cocaine relapse are summarized, and the outcomes of studies demonstrating efficacy in human addicts are described. Finally, an overview of the safety profile of l-THP is provided and challenges associated with FDA approval of l-THP are discussed. I think the following below links may help you in your analysis:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878639/pdf/nihms-538179.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150957/
Thanks
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