Dear ResearchGate Community,

I am currently seeking a laboratory attachment opportunity and potential grant support or sponsorship to carry out my research project titled:

“Molecular Modeling and Synthesis of Benzylidenechroman-4-One Derivatives as Potential Acetylcholinesterase and BACE-1 Inhibitors for the Treatment of Alzheimer’s Disease.

Research Summary

This 12-month project combines computational drug design, synthetic organic chemistry, and biological evaluation. The goal is to design, synthesize, and assess novel benzylidenechroman-4-one derivatives using a molecular modeling approach, followed by biological screening for enzyme inhibition and antioxidant activity.

Objectives

Use molecular docking and ADMET tools to identify promising derivatives.

Synthesize selected compounds via Knoevenagel condensation

Perform in vitro AChE/BACE-1 inhibitory assays and antioxidant screening

What I Am Looking For

Laboratory attachment or hosting in a department of Pharmaceutical Chemistry, Medicinal Chemistry, or a related field, preferably with access to synthesis and bioassay facilities.

Grant support or donation (reagents, consumables, or financial aid) to supplement the cost of synthesis, analysis, and biological evaluation.

Target Institutions/Collaborators

Universities, research institutes, or pharmaceutical labs with a focus on drug discovery, neurodegenerative disease research, or natural product derivatives.

Contact Details

If your lab or organization can host or support part of this work—or if you can connect me with someone who can—please feel free to message me here or email me at:

[email protected]

Whatapp no. +2347039888700

I appreciate your time and consideration, and I look forward to building meaningful research collaborations through this network.

Best regards,

Maryam Ismail Usman

PhD Candidate Pharmaceutical Chemistry

Al-Qalam University, Katsina, Nigeria.