I came across from several articles that after Myocardial Infarction (MI) and other injuries, there is release of stem cells from bone marrow into circulation. Is there any natural or synthetic compound that also cause a release of bone marrow stem cells into circulation under normal conditions?
GM-CSF. It is given before harvesting
hematopoietic stem cells during
a blood stem cell donation.
Regards,
Joachim
Also G-CSF and other growth factors induce stem cell egress. AMD3100, a CXCR4 inhibitor/antagonist. Some chemotherapeutic agents such as cyclophosphamide...and multitude of other compounds.
Hope that helps
Borja
Is any of these growth factor or other drug is also used as therapy? like after MI, Stroke, Spinal cord injury? or any other condition?
There is limited evidence that those approaches may benefit patients after MI or stroke (for instance). I am not aware, however, if they are used routinely.
Hello
yes i agree with researchers , you can use BM by granulocyte colony-stimulating factor (G-CSF) add , there are Evidence for vasculogenesis and arteriogenesis found after delivery of BM-derived stem cells in transgenic mice with myocytes, endothelial and smooth muscle cells proliferating in the infarcted region .
you can see this artical in attachment
Good Luck
Filgen is used to stimulate Hematopoetic stem cells and mobilize them in circulation, is there is any other drug that can mobilize Mesenchymal stem cells?
According to following article TGF Beta play role for migration of MSCs but is there is any drug or injectable form of TGF beta which can be used for stimulation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479365/
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