Dear all
I read one literature in past, which discusses selection of solubilization technology based on the melting point and log P of active pharmaceutical ingredient.
The faint content back of the mind is:
There were two graphs, Log P on X-axis and Melting point on Y-axis
[1] Dose is less than 100 mg, what are the zones, where you choose (1) nanonization (2) liquid filled capsules and (3) solid dispersion as solubilization enhancement technology
[2] If dose is greater than 100 mg, then the similar selection based on zones
COuld you please help me find this reference?
This article is really a good read.
Thank you
I got this one. If anyone want to read this, please go through following link-
Article Support Tools in Formulation Development for Poorly Soluble Drugs
Journal of Pharmaceutical Sciences 105 (2016) 2260-2269
The formula that links the melting point (MP) with solubility (S) and activity coefficient (γ):
log S = 0.01(MP - 25) + log γ
is very crude and I do not recommend using it, rather use cosolvents for solubilization.
Dear Dr. Andrei Blasko
yes, I do agree with your comment. Solubilization of pharmaceutical compounds is a complex phenomenon and there are factors other than MP can affect the solubilization.
Moreover, in vivo conditions that include but not limited to presence of bile salts, pH of different parts of GIT, and mechanical movements can have further impact on the same.
You may check the paper that I mentioned in previous comment to this thread (link copied below). This publication summarizes various tools to support formulation development based on physicochemical properties of poorly water-soluble pharmaceutical molecule(s).
link: Article Support Tools in Formulation Development for Poorly Soluble Drugs
Sincerely
Samarth
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