I came across the two contradicting views that ROS levels must be low under low oxygen (microaerophillic) or in absence of oxygen (hypoxia).
Other researcher shows that ROS levels are high due to inhibition of ETC. Generation of superoxide anions by NADH dehydrogenase shown to play role.
I wish to knew what happens under physiological conditions in tuberculosis inside granuloma or macrophage where conditions are hypoxic or similar ?
I was working on M.avium and chicken and human cells, i found that the bacteria induce the host cells to produce high amount of ROS, and i found the bacterial growth were also enhanced inthe presence of Ros, but the bacterial CFU greatly reduced in the presence of antioxidants
Dear Samsher,
Unfortunately (or luckily), ROS are complicated and a collective name of many different reactive molecules. I don't work on mammalian systems but plants. Similarly, ROS bursts can occur upon entering hypoxia, but may decline (depending on the type of ROS) upon reaching anoxia depending on the type of ROS and organelle/tissue studied.
I would always suggest looking at their methods and check how and when they did their measurements and draw careful conclusions from there.
Best of luck
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