Hi all,
Considering that one has the whole genome sequence (annotated) of a bacterium and wants to know if it has the potential to cause human diseases, what steps would you recommend (insilico)?
I noticed that one of my novel species falls into the phylogenetic cluster of Pseudomonas aeruginosa and is closely related to P. alcaligenes (which was isolated from human blood samples and is also responsible for bioremediation purposes) based on genome tree.
Does this affiliation can be trusted with respect to the pathogenecity tendency?
Thanks,
Timsy
Phil Geis Thanks for an answer. Yes, you are correct. I am suggesting on the strain´s capability or potency to cause disease. Whether it cause a disease or not, that is something we can not know until physiological experiment in a model organism.
But for the first step, what would you suggest as an approch towards finding its pathogeneic nature?
I think, comparing the marker virulence genes of physiologically closest strain to the query genome.
Best,
Timsy
to provoke, suggest you look at the consideration of Burkholderia cepacia as an agricultural supplement.Article Agricultural Use of Burkholderia (Pseudomonas) cepacia: A Th...
Your bug may have virulence markers beyond those of the "closest strain"/species and you prob. should consider antibotic resistance as well.
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