Viral nucleocapsid proteins act as glue for the virion, binding the virus's nucleic acid, RNA or DNA, to the its lipid bilayer. Nuclear proteins must have a positive charge to bind the negatively charged phosphate backbone of the nucleic acid. They also must have stretches of hydrophobic amino acids that insert into the viral membrane. This is the structure of a basic secretagogue, e.g. mastoparan, compound 48/80, Substance P, etc., which can induce anaphylaxis. Such molecules have recently been shown to bind and activate the MRGPRX2 receptor uniquely present on mast cell membranes, resulting in IgE signaling in the absence of IgE.
Quercetin, a plant flavonoid present in the diet, is a high affinity (uM) inhibitor of MRGPRX2. It recently cured a patient of mine with COVID19 symptoms (http://www.scivisionpub.com/pdfs/quercetin-for-covid19-1196.pdf).
I am calling for:
1. Trials of quercetin as prophylaxis and treatment for COVID19, no matter how advanced the case.
2. Trials of quercetin, given its extraordinary safety, for all viral diseases, including dengue, Ebola, Chikungunya, hepatitis, etc.
Dear Dr. Moskowitz
I read in German Press ( I will later send you the link) that the scientist are researching in lab the efficacity of Quercetin against Covid19.
I am also aware of a trial to start this summer in Saudi Arabia.
https://ichgcp.net/de/clinical-trials-registry/NCT04468139
Best regards, Michaela
Dear Dr. Moskovitz
Please find a list with some clinical trials with quercetin as well as a case report from China, dated 2018. All the best, Michaela
Role of Quercetin for its antiviral activity in patients with COVID-19
Quercetin is a major flavonoid found in berries. It has been found to have anti-viral properties. Although, Quercetin has been used alone or in combination with other substances in experimental viral infections (1-4), there is no good quality data in the form of a randomized controlled trial in patients with COVID-19 patients to recommend or stop its use.
1. Preprint COVID-19 and Flavonoids: In Silico Molecular Dynamics Dockin...
2. Article Tripartite Combination of Candidate Pandemic Mitigation Agen...
3. Article Quercetin and Vitamin C: An Experimental, Synergistic Therap...
4. Article The effect of quercetin on the prevention or treatment of CO...
Perhaps one should not limit investigations to quercetin, but study polyphenols as a substance class, because many of these are naturally occurring. Other popular polyphenols are green tea (epigallocatechin gallate, EPGC) or reservatrol. Numerous studies have shown that these substances have a noticeable effect on various diseases. Furthermore, it was only recently published that these substances can serve as genetic stabilizers.
However, most clinical studies worldwide are financed by the pharmaceutical industry, and EPGC and quercetin are inexpensive and not protected by patents.
Therefore, political decisions have to be taken to finance such clinical studies.
https://www.nature.com/articles/s41598-020-62292-5
https://doi.org/10.1093/jaoac/102.5.1397