I would like to deliver the pdgf and vegf from prp into the dermis of human scalps and would like to know if you think it is possible to do so. Do you think that pdgf from prp can successfully be delivered via ultrasound? I mean apply the prp topically then apply the ultrasound. Thank you!
Several methods exist for improving transdermal drug delivery such as chemical
mediation using liposomes or chemical enhancers, and physical mechanisms such
as iontophoresis, lasers, electroporation, microneedles and ultrasound (also called
sonophoresis or phonophoresis. The use of needles for multiple injection of drugs, such as insulin for diabetes, can be painful. As a result, prescribed drug noncompliance can result in severe medical complications. Several noninvasive methods exist for transdermal drug delivery. These include chemical mediation
using liposomes and chemical enhancers or physical mechanisms such as microneedles, iontophoresis, electroporation, and ultrasound. Ultrasound enhanced transdermal drug delivery offers advantages over traditional drug delivery methods which are often invasive and painful. Transdermal ultrasound drug delivery technology offers promising potential for noninvasive drug administration. From a clinical perspective, few drugs, proteins or peptides have been successfully administered transdermally because of the low skin permeability to these relatively large molecules. The proposed mechanism of ultrasound has been suggested to be the result of cavitation, which is discussed along with the bioeffects from therapeutic ultrasound. For low frequencies, potential transducers which can be used for drug delivery are discussed, along with cautions regarding ultrasound safety versus efficacy. Numerous studies of these methods have shown that ultrasound mediated transdermal drug delivery offers promising potential for noninvasive drug administration. Fact is that ultrasound drug delivery is not confined only to transdermal applications. A large body of work focuses specifcally on delivery to internal organs, but does not cover tissues or gene delivery.
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