Hi Fahim,

Denaturation is unfolding the protein structure. It means the loss of its secondary, tertiary or quaternary structure due to exposure to a physical or chemical factors. While the primary structure stays intact because it is formed by covalent bonds between amino acids that are more stronger than the non covalent bonds forming the secondary and tetertiary structure of protein. When a protein denatures, it changes from three dimensional shape to linear amino acid sequence. In this case, all the biological functions of a denatured protein are lost.

However, when a protein is degraded, the primary structure is destroyed. It means that the covalent bonds between different amino acids are broken. This case can be happen by enzymes called proteases. Protein can be completely decomposed to its amino acids or broken to small peptide chains.

The majority of physical factors such as drying, freezing and heat treatment cause denaturation effects on the protein structure.

Denaturation of proteins involves the disruption and possible destruction of both the secondary and tertiary structures. Since denaturation reactions are not strong enough to break the peptide bonds, the primary structure (sequence of amino acids) remains the same after a denaturation process.

Degradation of proteins involves the destruction of primary structure of protein. It means that the covalent bonds between different amino acids are broken. It can be happen by enzymes called proteases. Protein can be completely decomposed to its amino acids or broken to small peptide chains.