Hi, this is my first post:

following the method of this article : Article The BRCA1 Tumor Suppressor Binds to Inositol 1,4,5-Trisphosp...

By using, PSSM , maybe HMM methods to find similarity in sequence alignment, using 3D structure , PSI - BLAST, Ada-BLAST...

I would like to know since this article was published (2015) if they are now other better and efficient methods ? HMM and PSSM are quite old methods but constantly used today.

I'm open to any suggestion !

Y.B