ANOVA or Paired samples t-test?

Hi, I'm a masters student struggling with the design of my cognitive psychology project. We wish to run an experiment where we examine false memory recall using a list of schema related nouns in...

13 February 2021 6,457 3 View

How to tackle autofluorescence using the technique FISH in mouse frozen tissue?

Hi there, I am looking for some advice with FISH. This is my first time attempting this technique and I am not too sure where I could potentially be going astray. I have followed FISHTag RNA...

23 September 2020 3,849 1 View

How to customize a 'plt.var' plot from CCA package?

Hello, I'm trying to customize a CCA biplot made with the plt.var function from the CCA package. I need to reduce the size of the labels or be able to move those labels because they overlap on...

31 July 2020 2,938 3 View

What are the effects of Covid 19 on nursing students and faculties?

Due to crisis of Covid 19 students have to disconnect from their education system and for preparing nurses its must to relate the theory with skill labs and then hands on practice is required to...

17 May 2020 7,462 21 View

How does hypertonic tissue appear in sliding filament theory & how do the number of myosin heads in a hypertonic area affect muscle strength?

30 March 2020 2,169 5 View

Some participants completed their demographic details and some other questions but did not answer ANY of the scales. What should I do?

Should I include their demographic information in the demographics section Of my sample? Or should I delete them? Do I need to report on this?

01 October 2019 8,146 2 View

Analytics of Egress from the location of a Fire?

Hi All, A student of mine is gathering data on what people do when encountering a fire in the home. This data will then be analysed. There is much research on what happens when the fire occurs in...

17 June 2019 3,030 2 View

Can a fish biologist help identify this species from Madagascar?

This animal was caught by a fisherman in northwestern Madagascar, about a month ago. It had a long, thin, cylindrical body, at least 0.9 m in length, and appeared not to have any scales. The head...

06 November 2018 3,459 3 View

Reliability coefficient for two-item scales: Cronbach, Pearson, or Spearman-Brown?

Colleagues, Which index of reliability do you use for two-item scales, and what is your justification for so doing? Respectfully, Ruth

19 September 2018 475 2 View

Does anyone have experience of tetrachoric correlation with missing data?

I have binary data that I want to run a factor analysis on in Stata. I can run this fine using tetrachoric correlation, but I have nearly 50% missing data, so I really need to impute the data. I...

18 June 2018 6,052 2 View

I am interested in medicinal chemistry field, which books are highly recommended to learn from?

I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...

02 March 2021 8,437 2 View

How to empty large intestine in mice ?

Hi all I am working on colon-targeted drug delivery for which I kept mice fasting for 6h using fasting grills during scotophase (dark period). I observed liquid fecal content in the cecum and...

23 February 2021 7,701 2 View

Can I use a protein-devoid condition as my negative control in ELISA?

Hello, I am running a sandwich-type ELISA where I am trying to inhibit a protein-protein interaction using small molecules. For each experiment, I determine my Z' (Z-prime) to determine the...

23 February 2021 7,429 1 View

How does the injection volume impact LLOQ and ULOQ in regression analysis (LC-MSMS)?

Hello, I have run into an issue that has sparkled a debate at work: is the LLOQ/ULOQ impacted by injection volume under the following circumstances: 1) Same dilution factor of all samples 2)...

23 February 2021 9,159 3 View

Can two EC50 values with different hill slopes be compared?

Hello, I fit a classical dose response curve Y=Bottom + (Top-Bottom)/(1+10^((LogEC-X)*HillSlope)) to my data (not related to inhibitors etc). The model I use is purely qualitative but it fits...

23 February 2021 8,155 5 View

Which alginate is best for making gel for wound dressing application?

We are looking into utilizing alginate as a gel coating on an HDPE substrate for drug delivery. I would like to ask the community about their experience with alginate and which commercial sources...

15 February 2021 4,319 4 View

Any natural extract (that is easily available) or any drug combination triple which i can use against gram negative?

I'm working on gram negative i want to use any natural extract (plant extract) or triple drug combination against its biofilm formation.

14 February 2021 1,403 3 View

Should the AUC in a concentration-time graph of a subcutaneous implant be roughly the same for poeple?

I have 2 concentration time curves of a subcut drug implant. the first group has a peak around the 50 day mark where as the second group does not. Both groups received the same implant by the same...

10 February 2021 2,305 3 View

XRPD Quantification - Building a calibration curve of drug excipient?

I am aiming to utilise XRPD to quantify a drug excipient within a drug product and have been having a little trouble building the calibration curve to allow for this quantification up until this...

10 February 2021 6,145 3 View

Is this grounds for theophylline toxicity even though her plasma is within the therapeutic range? if it is, how is that possible?

A patient was given 300 mg Theophylline taken twice a day for the treatment of her bronchial asthma and has a positive clinical response. She has been compliant in taking her medication however,...

09 February 2021 3,489 3 View