As you know the scar in the SCI patients and animal models forms inside the spinal cord tissue and forms a cavity but there are a lot of investigations that applied electrospinning nanofibers for motor neuron recovery and astroglioal scar decrement. I think the sheets of electrospinning nanofiber just affects through mechanotransduction pathways and its effects is not direct and maybe hydrogel based scaffold is a true option instead of it. Electrospinning nanofiber is a good option for peripheral nerve regeneration not SCI. What is your opinion about it?
HI,
I think one important thing with SCI is the same for peripheral nerve regeneration: guide/direct the gial cells and neuron growth in only one direction to fill a nervous gap (CNS or PNS). According to me aligned electrospun fibers thus represent a good way to achieve this (successfull in vitro studies have also been published on both CNS and PNS cells). The main concern with hydrogel would be the random growth of cells, impairing the filling of the defect.
thanks a lot Guillaume, but when you implant an aligned nanofiber in a site far from of SCI defect, out of cavity, how it directs cells around the cavity?
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