Picrotoxin convulsions?

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Tejas Ganatra

According to HG Vogel,

You can use Picrotoxin in dose of 3.5 mg/kg, S.C. for Mice and observe the symptoms like Clonic seizure, Tonic seizure and Death during next 30 minutes...

For more reference, here I have attached that Book also which give idea about all type of animal models of Epilepsy and all other diseases...

Nikola M Stojanovic

Many thanks!!!

However our animals didn't convulse with 7.5mg/kg of PCTX....and no mortality after 24h was observed! (both in control postive, negative and in substance treated animals)

Md. Jahir Alam

You may try with 8 mg per kg bw (Intraperitonially) as I used and observed convulsion within 3-4 minutes in control mice.