Is it possible to synthesis a penicillin that can bind covalently to a beta-lactamase?. Although when it binds, it will still result in a form of hydrolysis, but the enzyme will theoretically remain occupied with the hydrolyzed drug resulting in un-functional enzyme. bacteria strain then would need sometime to reform another enzyme allowing the unbound drug to carry its effect even before it finishes the synthesis of a new enzyme.
What you have described is a beta-lactam-type of serine beta-lactamase inhibitor. These include clavulanic acid, sulbactam, and tazobactam. Although these are not technically in the penicillin class of beta-lactams, they inhibit beta-lactamases by reacting with the active site and remaining there. Recently, additional classes of beta-lactamase inhibitors have been developed: the diazabicyclooctanones and vaborbactam.
β-Lactams and β-Lactamase Inhibitors: An Overview - NCBI
www.ncbi.nlm.nih.gov › pmc › articles › PMC4968164
Jump to PENICILLINS — Among the penicillinase-stable penicillins of clinical significance are methicillin, oxacillin, cloxacillin, and nafcillin, with the latter ...by K Bush · 2016 · Cited by 257 · Related articlesAbstract – CEPHALOSPORINS – CARBAPENEMS – β-LACTAMASE INHIBITORS
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