In the KrasLSL-G12D/+;Pdx1-Cre PDAC mouse model, at which time does metastasis start to form in lung and liver? And at what frequency?
As far as I know, the distant metastasis occurs in the lungs, liver, diaphragm and adrenals and all of them die before 12 months in KrasLSL-G12D/+;Pdx1-Cre PDAC mouse model.
In addition, KrasLSL-G12D/+;Pdx1-Cre PDAC mice harbor precursor lesions, or pancreatic intraepithelial neoplasia (PanIN) by 8 to 10 weeks of age.
[References]
* World J Gastroenterol. 2012 Mar 28; 18(12): 1286–1294.
Mouse models of pancreatic cancer
* Curr Protoc Pharmacol. 2016 Jun 1;73:14.39.1-14.39.
Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (LSL-Kras(G12D/+) ;LSL-Trp53(R172H/+) ;Pdx-1-Cre), Its Variants, and Their Application in Immuno-oncology Drug Discovery.
According to the above articles, while most of the individuals die within the short period, some of them who survive longer than 20 weeks exhibit the distant metastasis to the lungs and liver and peritoneum dissemination by all means.
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