If pattern electroretinogram is an electrophysiological response obtained by stimulation of the central retina (macula) and we know that mice have no macula then wouldn't it be inappropriate to use PERG to check visual function in mice?
I'm not an expert, but the PERG comes from the inner retina - especially ganglion cell layer. As such, it reflects full-thickness retinal function via outer retinal inputs. It is mainly a macular tests because that's were the majority of the ganglion cells are. As mice have ganglion cells, you should be able to use it with mice. It is a very finicky test, so a single or few tests in a few subjects is hard to rely on. Many tests in a number of subjects is more meaningful. Take great care in uniform testing procedures / environment and use of a single machine and staff to improve reproducibility.
The pattern electroretinogram (PERG) provides an objective measure of central retinal function, and has become an important element of the author's clinical visual electrophysiological practice. The PERG contains two main components, a positivity at approximately 50ms (P50) and a larger negativity at approximately 95ms (N95)
Which PERG device can allow the stimulus pattern to project to the center of the mouse retina?
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