I think that analysis of particle size & shape using optical microscope should be included as one of the tests in the official monographs(e.g, BP & USP) for oral suspensions. I have seen during my work in drug quality control field that such test is important and can explain the physical characters of different oral suspensions & can help to confirm that the suspension passes or fails the pharmacopoeial requirements. What do you think ?
Particle size measurement by optical microscopy is not a very good idea. It is tiring and you do not get enough samples to run meaningful statistical tests for shape distribution.
Thank you for your opinion Dr. Teodoro, but my question is that why can't we include such test for oral suspensions while it is already present in the British Pharmacopeia (for example) as a routine test for many injectable and ophthalmic suspensions? moreover, from my experience, it is not a tiring procedure and takes only 1 or 2 drops from the liquid suspension to study the size and nature of particles and can be done on multiple containers (if required) to get reliable statistical data from a certain batch.
Best regards
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