Hi there,
Would like to ask some opinions from you all out there.
Lets say I have a mouse dosing study to study the effect of drugs A and B in tumor bearing mice.
Therefore, my treatment groups will be Drug A, Drug B, Drug A + B, Vehicle only (control).
However, if the schedule for drug A is to be given twice a week, and drug B once a week, that means I will need to have 2 vehicle only groups (one group receiving once a week and the other receiving twice a week)?
It wouldn't be scientifically sound if I just had one vehicle group only, right?
Dear Stephen Wong,
Look the link, may be useful.
http://www.mogi.bme.hu/TAMOP/jarmurendszerek_iranyitasa_angol/ch02.html
Regards, Shafagat
Dear Shafagat,
Thanks for your input, but the one you gave me is literally automotive control!
By vehicle control, i meant the media used to deliver the drug into the mice. So my control groups will have only the media without the drug.
So, there is a difference between scientifically sound and scientifically justifiable (cost also plays a factor here). No, you would not have a complete study design, but it is also the researcher's job to reduce harm, so justifying two vehicle groups may not always be best.
In this case, the vehicle group expected to have the most effect may be used (so, the twice a week).
It's arguable, to be a complete design, you would also need a naive group (no vehicle), but that is a frequently excluded group from studies.
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