Please check

1) Nagwa E.A.Gaboon. Nutritional genomics and personalized diet. Egyptian Journal of Medical Human Genetics.Volume 12, Issue 1, May 2011, Pages 1-7

2) Murgia C, Adamski MM. Translation of Nutritional Genomics into Nutrition Practice: The Next Step. Nutrients. 2017;9(4):366. Published 2017 Apr 6. doi:10.3390/nu9040366

3) Dean DellaPenna. Nutritional Genomics: Manipulating Plant Micronutrients to Improve Human Health.Science 16 Jul 1999: Vol. 285, Issue 5426, pp. 375-379

4) Daiva E Nielsen; Ahmed El-Sohemy. Applying Genomics to Nutrition and Lifestyle Modification.Personalized Medicine. 2012;9(7):739-749.

Food genomics, also known as nutrigenomics, is a science that studies the relationship between human genome and nutrition and health. People in this area are developing an understanding of how the whole body responds to food through the biology of systems, in addition to single-gene compound relationships.

Thank you Zainab A. Makawi Entedhar Sarhat Pei-chee Wung

Grateful indeed

But how does food can cause issues to body. Is it that the food may appear as allergens as happens so in coeliac disease?

May be that not everybody is good to everybody and kids once denying a certain food, could be an indication that they are allergic to that beacuse of some abnormality in their genes?

Regards

Very impressive topic to explore.

Following

Nutritional genomics, also known as nutrigenomics, is a science studying the relationship between humangenome, nutrition and health. People in the field work toward developing an understanding of how the whole body responds to a food via systems biology, as well as single gene/single food compound relationships.

Information is power. Thanks.

That this discovery is one of the most dangerous discoveries in the history of mankind, it is a new depth to know the human from the inside.

Nutrigenomics has been described by the influence of genetic variation on nutrition by correlate the gene expression with a nutrient’s absorption, metabolism and how it is eliminated from our body. Once the nutrient interacts with such system, it alters the gene, metabolite production and protein expression in depending on the level of nutrient it detected. Hence, different diets will elicit different patterns of gene, protein expression and metabolite production. Such patterns of effects have been referred to as dietary signatures, where they are examined to investigate how homeostasis is influenced.

Nutrigenomics is also able to demonstrate the impact of bioactive food compounds and its effect on human health, which should lead to the development of functional foods that will keep people healthy based to their individual needs. Then, this will further prevent development of chronic diet-related disease such as cardiovascular diseases, obesity and Type 2 diabetes mellitus.

Nutrigenomics has great potential to benefit medical science in the future. Moreover, nutrigenomics tests and researches need a large study population of patients and controls to investigate combinations of genetic variants and impact of nutrients in relation to a disease.

Hi every one

I agree with all answers above

Nutrigenetics focuses on the impact the changes in our genes (also referred to as polymorphisms) have on our potential health path, which is strongly influenced by food, nutrition, stress, and toxins.

Regard

Although much has been learned about nutrigenetic testing and nutrigenomic interventions in the last 15 years since the completion of the Human Genome Project, there are many questions yet to be answered for us to rely on its clinical utility. Many of its principles have been misinterpreted - and overinterpreted by slick marketers who are exploiting the science to their financial gain.

A case in point lies with SNPs of the MTHFR gene, which has been greatly overinterpreted. Consumers - and many clinicians - are unable to see that this gene, as it has always existed, is not necessarily indicative of serious disease.

And yet, individuals seem to believe that knowledge that they carry heterozygous or homozygous SNPs is something of a death sentence. A diet rich in certain B vitamins is capable of overcoming the effects of these SNPs. However, some marketers are promoting 5-methyl folate supplements up to 40-fold higher than the RDA for folate.

As a consequence, perturbation of metabolic pathways can result in severe adverse effects. The same promoters then sell a high dose niacin supplement to counter the adverse effects of high folate.

What this means in my opinion, is that genuine researchers and clinicians in Nutritional Genomics can have their reputations tarnished by the nonsense that is occurring in the retail space, especially when individuals are encouraged to answer a questionnaire in order to determine the likelihood that they carry specific SNPs as distinct from undertaking a scientifically-validated nutrigenetic test.

A recently-published book is an example of what I see as the bastardisation of the science. And yet, the book is regarded by consumers and many clinicians as 'excellent' - it is available on Amazon.

Dear@Christine

it was quite comprehensive. What i interpret is that epigenetic changes resulting because of nutritional intake MA or MAY NOT turn into DISEASE. So mere presence of a methylated or epigenetic mark may not imply a pathology.

I hope i am correct in my interpretation

regards

Nutritional genomics, also known as nutrigenomics, is a science studying the relationship between human genome, nutrition and health. It focuses on the role of specific foods which activate genes that affect susceptibility to certain illnesses such as Alzheimer’s disease and cancer. Thus nutritional genomics provides the basis for personalized dietary recommendations based on the individual's genetic make up. Please take a look at the following RG links for more details.

Article Nutritional genomics: A review

Article Nutritional Genomics

Article Translation of Nutritional Genomics into Nutrition Practice:...

Technical Report Nutritional Genomics: A Step Towards Personalized Nutrition

Thank you very much Arvind Singh , like always so very specific and comprehensive

regards

Sikandar Hayat Khan . You are correct in saying, "So mere presence of a methylated or epigenetic mark may not imply a pathology."

As we often say, genetics loads the gun; the environment pulls the trigger! I have seen patients with numerous SNPs on a range of genes governing key upstream cellular metabolic processes - and yet be healthy. These same individuals typically observe a very health-promoting lifestyle!

Thanks a lot Christine Houghton

i will remember your words "genetics loads the gun; the environment pulls the trigger "

Regards

Obesity is one of the most widely studied topics in nutritional genomics. Due to genetic variations among individuals, each person could respond to diet differently. By exploring the interaction between dietary pattern and genetic factors, the field aims to suggest dietary changes that could prevent or reduce obesity.

Nutrigenomics also seeks to provide a molecular understanding of how common chemicals in the diet affect health by altering the expression of genes and the structure of an individual's genome. The premise underlying nutrigenomics is that the influence of diet on health depends on an individual's genetic makeup.

https://www.medicinenet.com/script/