Definitely, we should not fold our arms in the wake of the fast evolving knowledge on SARS-CoV-2 mutation. Currently, a new British strain, B.1.1.7, sets off a scary alarm intensifying the threat of COVID-19. Even though, SARS-CoV-2 ; (1) has a slow mutation rate (2) belongs to a group of viruses with proofreading mechanism and (3) and that the current knowledge in designing the vaccine is centered against the non-essential region. Are these enough to relax that the available and upcoming vaccines can guarantee our safety assurance as a preventive mechanism?
The available COVID-19 vaccines such as Pfizer, Moderna and Covaxin are effective against the new variants of SARS-CoV-2.
Preprint Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccin...
Preprint mRNA-1273 vaccine induces neutralizing antibodies against sp...
Preprint Neutralization of UK-variant VUI-202012/01 with COVAXIN vacc...
Article Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by ...
Experts are still confident that will be effective against this strain as well
This second "phase" confirms the novelty of the deadly virus. Just like you stated "we should not fold our arms in the wake of the fast evolving knowledge on SARS-CoV-2 mutation". We hope for a quick solution. Local/regional control and therapeutic measures should be thoroughly researched and we should not all depend on a particular source for cure.
Well, as we all know that the single mutations will generally have small impacts on the polyclonal immune responses and the strong immune response to the mRNA vaccine would suggest that a large antigenic change would be needed to significantly reduce the efficacy. However, we may see modest reductions in vaccine efficacy due to antigenic drift and will likely need a process in the coming years by which we update the spike variant used in the vaccine to best match the circulating virus.
It has been already discussed that it'll be helpful in containing the new strain.
Source: https://www.rediff.com/news/report/covid-vaccine-will-be-effective-against-new-mutant/20201221.htm
La alarma es necesaria para seguir investigando, sabemos que las vacunas son eficaces y se van mejorando con el tiempo. Esa es la realidad, lo importante es que ya la vacunación se inicio en varios paises, no cruzarse de brazos, seguir investigando es nuestra obligacion.
The available COVID-19 vaccines such as Pfizer, Moderna and Covaxin are effective against the new variants of SARS-CoV-2.
Preprint Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccin...
Preprint mRNA-1273 vaccine induces neutralizing antibodies against sp...
Preprint Neutralization of UK-variant VUI-202012/01 with COVAXIN vacc...
Article Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by ...
Moderna’s COVID-19 vaccine neutralizes all circulating variants of SARS-CoV-2.
Preprint mRNA-1273 vaccine induces neutralizing antibodies against sp...
Cierto, la mutación del virus continuara, las vacunas cada año serán mas eficaces, así se ha trabajado por muchos años. Lo positivo es que hay vacuna que protege a las personas. Unas son mas eficaces que otras, irán mejorando con el tiempo. Ese es el mensaje que debe darse a la población, porque mientras mas vacunados tengamos en el mundo, menor morbilidad existirá. No se debe confundir a la población con el tipo de vacuna, estará la vacuna que su pais adquirió.
Arvind Singh thank you for the materials for further reading. Your contribution is appreciated.
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