The production of cytokines is an important factor in the inflammatory process. On the other hand, natural products derived from medicinal plants appear to be (and often are) promising pharmacological tools to modulate cytokine production. Monorterpenes are promising substances that have modulated cytokine production in vivo (preclinical and clinical approach) (See: Monoterpenes modulating cytokines - A review. Food Chem Toxicol. 2019;123:233-257. doi: 10.1016/j.fct.2018.10.058 or Essential oils and its bioactive compounds modulating cytokines: A systematic review on anti-asthmatic and immunomodulatory properties. Phytomedicine. 2020; 73:152854. doi: 10.1016/j.phymed.2019.152854). The role of flavonoids is well known in the inflammatory process, especially when it comes to the production of cytokines (see: lavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases. Int J Mol Sci. 2016;17(6):921. doi: 10.3390/ijms17060921 or Flavonoids as Th1/Th2 cytokines immunomodulators: A systematic review of studies on animal models. Phytomedicine. 2018;44:74-84. doi: 10.1016/j.phymed.2018.03.057). Several other natural products are promising, but how many of these have become drugs available on drugstore shelves? What is the biggest challenge to getting natural products that are modulators of important cytokines, such as cavacrol that modulates IL10 (Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10. Eur J Pharmacol. 2013;699(1-3):112-7. doi: 10.1016/j.ejphar.2012.11.040), to be available for clinical use? Briefly share your opinion. I'm writing an article that thinks about this a bit and would like to read the opinion of other researchers who are interested in the topic.
Dear Lucindo José Quintans-Júnior
Great question. I Think the area of Natural Products research should be expanded significantly. Updated review of Newmann & Cragg (2020) shows natural products as sources of new drugs since 1981. Atanasov et al. (2021), speak: "Natural products have high structural diversity and various bioactivities that can be directly developed or used as starting points for optimization into novel drugs. Nevertheless, also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization, and optimization, e.g. But, technological and scientific developments such as improved analytical tools, genome mining, and engineering strategies, are addressing such challenges and opening up new opportunities".
Article Natural Products as Sources of New Drugs over the Nearly Fou...
Article Natural products in drug discovery: advances and opportunities
Sincerely yours,
https://www.researchgate.net/publication/233766948_Review_of_natural_products_actions_on_cytokines_in_inflammatory_bowel_disease,this link may be useful.
https://www.sciencedirect.com/science/article/abs/pii/B9780444641854000137,also u can check this link.
Dear Dr Lucindo José Quintans-Júnior . Please the following useful RG link: Article Natural Products for the Treatment of Autoimmune Arthritis: ...
Kindly check also the following very good RG link: Article Head-to-Head Comparison of Anti-Inflammatory Performance of ...
Also check please the following useful RG link: Article Modulation of proinflammatory cytokines and enzymes by polyh...
Kindly check also the following good RG link: Article Natural products provide a new perspective for anti-compleme...
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