A 60 year old man had a kidney transplantation for 30 years consulted for his allo graft dysfunction with blood urea of 100mg/do and serum creatinine of 2.9mg/dl.He had a lo g history of bilateral lyphodema of lower limvs.He had a 2+protein in urine and normal other lab.results.his abdominal Ultrasound and doppler showed a raised RI of the grafted kidney and his pancreas showed a suspicious mass at the head of it His MRCP showed a multiple different sizes cystic masses that most likely a mucinous cystic masses and a malignant cystic carcinoma needs further evaluations question is there any relation between mTor inhibitors rapamycin abd tbeses findings?