MR-physics people: Does anyone have experience doing contrast-enhanced CSF studies using MRI (gadolinium in CSF)? I am not sure of how to find the best injection concentration of gadolinium to use and also what MR parameters are best to obtain the data. Your advice would be greatly appreciated!
There are a number of publications about contrast-enhanced MR cisternography (e. g., the review article by Algin and Turkbey attached below). In the attached article, a volume 0.5 mL of Gd-DTPA is (diluted and) injected, which results in a similar contrast-agent concentration in CSF (total volume of 150 to 200 mL) as in blood (5 L) after i.v. administration of a single dose (of about 15 mL) of Gd-DTPA.
(Intrathecal Gd injection is not approved by the FDA.)
Article Intrathecal Gadolinium-Enhanced MR Cisternography: A Compreh...
Olaf, thanks so much for this article reference! Extremely instructive and helpful!
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