Also I would like to ask about the possible link between Th17 response and the induction or proliferation of this cells.
Given their morphologic and functional similarities to T and NK cells, most have presumed these cells are lymphocytes and therefore would share a common precursor with T, B, and NK cells, such as the CLP phenotype or a LMPP phenotype. This also conforms with their dependency on gamma-c. Recently, work using a Rag1-reporter/deleter provided evidence that this is true. See http://www.jimmunol.org/content/187/11/5505.
It seems likely that the various definitions for Nuocytes, NHC, Ih2, etc, etc, reflect highly related cells which have acquired differential phenotype/function based on tissue localization and/or activation signals. MPPtype2 cells as initially reported (http://www.nature.com/nature/journal/v464/n7293/abs/nature08901.html), however, exhibit the ability to generate myeloid cells. This would suggest that MPPtype2 cells are derived of a progenitor prior to the common T/B/NK precursor and, despite functional similarities to Nuocytes/NHC/Ih2, are developmentally very different cells.
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