Natural product drug discovery process depends on the purification and identification of a molecule from a mixture. The purification is being carried out based on the activity or spectral analysis. Here, we need to identify each and every small molecule from a bacteria/plant/animals. We are not considering the molecules expressed in nanomols or picomols (detected in a low level like a baseline peak) from an extract. But this may have the novel structural scaffolds not yet discovered so far. Considering this, we need to identify each and every molecule from a bacteria/plant/animal. How to make it possible?