Dear Mehwish Faiz

Basically, Assigning the sub-cellular location of a protein is of paramount importance to biologists in the elucidation of its role and in the refinement of knowledge of cellular processes by tracing certain activities to specific organelles.

Kind Regards

Qamar Ul Islam

Dear Mehwish Faiz ,

Not entirely sure what you’re aiming for, but a good starting point might be:

Sadowski, P. G., Groen, A. J., Dupree, P., & Lilley, K. S. (2008). Sub‐cellular localization of membrane proteins. Proteomics, 8(19), 3991-4011. (See enclosed file).

See also (some) of the efforts of one of the best research groups in this field, the Rost Group (https://rostlab.org/group/about):

https://www.rostlab.org/services/locdb/

and TOPCONS from one of the best universities in this field:

https://single.topcons.net/

Best regards.

You may want to start with these databases:

mpstruc - membrane proteins of known 3D structure

https://blanco.biomol.uci.edu/mpstruc/

mpstruc is a curated database of membrane proteins of known 3D structure. To be included in the database, a structure must be available in the RSCB Protein Data Bank (PDB) and have been published in a peer reviewed journal. The database is manually curated based upon on-going literature surveys. Because of the labor involved, new structures are not posted until they are released by the PDB and the complete reference, including pagination for print journals, is available in PubMed.

membranome 2.0 database

https://membranome.org

Membranome database provides structural and functional data about single-spanning (bitopic) transmembrane proteins of six organisms (human, thale cress flowering plant, slim mold, baker's yeast, gut eubacteria, thermophilic methanogenic archaeabacteria) representing all kingdoms of life.

It includes evolutionary classification, topology and intracellular localization of bitopic proteins, protein-protein interactions and known protein complexes, links to three-dimensional structures and metabolic pathways, and computationally generated models of transmembrane domains optimized in the lipid bilayer.

I am not sure you might need a protein membrane structure predictor

A curated web server for this:

http://htp.enzim.hu

Description:

doi: 10.1186/s13062-015-0061-x

Dobson L, Reményi I, Tusnády GE. The human transmembrane proteome. Biol Direct. 2015;10:31