I think that
"The importance of Mycobacterium bovis as a zoonosis. Authors: Charles Thoen, Philip LoBue, Isabel de Kantor. doi:10.1016/j.vetmic.2005.11.047" and
"Limited Transmission of Multidrug-Resistant Tuberculosis Despite a High Proportion of Infectious Cases in Los Angeles County, California". Authors: Annette T. Nitta et al. doi: 10.1164/ajrccm.165.6.2103109
may be of help. Regards Maria Julia
Hi!
I agree with the reference provided by Julia.
also, I believe that the cases of transmission (animal to animal and animal to man) should be investigated deeply in terms of success of transmission and via which route and are there any hallmark differences in disease course, manifestations and virulence if the transmission was directly contracted from an animal (and via what route?) compared to human to human transmission (and via which route?)
the last part of the question "is there any evidence" is a very interesting question indeed. the difficult part about the ethical consideration of Tuberculosis research, particularly handling of isolates, culture and drug susceptibility testing is that it can only be approved or authorized in a reference laboratory for tuberculosis or an authorized culture and drug testing facility of the same.
it would also be interesting to consider the question, what are the actual sources of the MDR TB in cattle? is the drug resistance acquired while the TB was in the animal? if so how? is this related to the antibiotic classes taken by the cattle? or was the drug resistance acquired thru the environment? in this case from water sources treated with TB then exposed to a wide variety of antibiotics (there are a lot of published articles regarding antibiotics in water and the drug resistance it contributes to the contaminating organism) or lastly, was the MDR TB of the cattle acquired from man? now that would be an interesting scenario of a man infecting an animal with a drug resistant strain.
i wish you all the best in your research, this in my opinion is a field of TB which has great potential for significant discoveries!
Hello,
I'm not sure if there is any report of cattle-to-human transmission (except for M. bovis infection due to consumption of unpasteurized milk), but there was a recent report of possible elephant-human transmission reported in the CDC's MMWR (Weekly
January 8, 2016 / 64(52);1398-1402).
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