The journal article "Endocardially Derived Macrophages Are Essential for Valvular Remodeling" by Shigeta et al. sheds light on other roles of macrophages. Aside from immunity, macrophages also takes part in valvular remodeling by phagocytosing unnecessary extra tissues. Does anyone know of other research that gives information of other roles of macrophages, especially roles on tissue formation.
There is substantial literature on macrophages and tissue repair, especially anti-inflammatory macrophages (M2). There are also transiently beneficial action in pathological conditions like Multiple Sclerosis, where they remove myelin breakdown products phagocytically. Article Macrophages in Tissue Repair, Regeneration, and Fibrosis
Article Myelin-laden macrophages are anti-inflammatory, consistent w...
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