01 January 1970 6 10K Report

Well, how about that? Two days after posting my article identifying layer 5 pyramidals (and specifically, components of their greater axons) as the site of subjective experience

Preprint The Location of Consciousness in the Brain

see also

Preprint The Neural Correlates of Feeling That Explain Consciousness

I find this article

Article General anesthesia globally synchronizes activity selectivel...

General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons

  • April 2022
  • Neuron 110(12)
  • DOI:
  • 10.1016/j.neuron.2022.03.032
  • License
  • CC BY-NC-ND 4.0
  • Lab:
  • Conzelmann Lab
  • Arjun Bharioke
  • Martin Munz
  • Alexandra Brignall
  • Show all 11 authors
  • Botond Roska

"Abstract

General anesthetics induce loss of consciousness, a global change in behavior. However, a corresponding global change in activity in the context of defined cortical cell types has not been identified. Here, we show that spontaneous activity of mouse layer 5 pyramidal neurons, but of no other cortical cell type, becomes consistently synchronized in vivo by different general anesthetics. This heightened neuronal synchrony is aperiodic, present across large distances, and absent in cortical neurons presynaptic to layer 5 pyramidal neurons. During the transition to and from anesthesia, changes in synchrony in layer 5 coincide with the loss and recovery of consciousness. Activity within both apical and basal dendrites is synchronous, but only basal dendrites’ activity is temporally locked to somatic activity. Given that layer 5 is a major cortical output, our results suggest that brain-wide synchrony in layer 5 pyramidal neurons may contribute to the loss of consciousness during general anesthesia."

The evidence has accumulated on a long-sought answer: Where is phenomenal consciousness occurring in the brain? Finally, we have a small area to zoom into for further study.

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